Jesse Custer struggles to escape a past of crime and violence. A renegade angel-demon spawn comes to Earth looking for a host. And an Irish vampire named Cassidy lands in Texas.

We get our first glimpse of the enigmatic Cowboy whose story of the past parallels the present day. Jesse is hunted by two angels looking for the escaped entity inside him. Then, meet the richest, most sinful man in town.

Jesse tests the limits of his new power on the town bully. Jesse's ex-girlfriend Tulip tries to draw him back to his old way of life to take revenge.

Jesse risks losing his church after he bets known atheist Odin Quincannon that he can lead him to God. Cassidy makes a deal to bring Jesse to the angels and has a run-in with Tulip.

Jesse uses the Word of God to help many in town, including the badly disfigured Eugene (Arseface), but soon learns his new ability might not be divine. The Cowboy makes a tragic decision.

The angels reveal all to Jesse about the true nature of his power, known as Genesis. An even more powerful angel comes to Annville to also hunt Jesse down. A tense argument with Arseface ends in disaster.

Jesse wrestles with the consequences of his actions with Eugene and reflects on his heartbreaking childhood. As tension mounts, Jesse alienates both Cassidy and Tulip.

Jesse faces off against Odin and his men as they attempt to take the church by force. The angels try one last time to retrieve Genesis from Jesse. Tulip becomes preoccupied with saving a friend.

Jesse is on the run from Sheriff Root, but plans to save his church by literally calling down God. The Cowboy exacts revenge on the town of Ratwater, which has a surprising connection to Annville.

Jesse and his congregation call Heaven in an attempt to get answers from God. After learning a shocking truth, Jesse, Cassidy and Tulip set out on a new mission.